Yıl 2016, Cilt 20 , Sayı 3, Sayfalar 425 - 431 2016-12-01

Synthesis of Monastrol, Kinesin-5 inhibitör and ınvestigation of its charge transfer complexes
Kinesin-5 inhibitörü olan Monastrol bileşiğinin sentezi ve yük transferi kompleks etkileşmelerinin incelenmesi

Mustafa Arslan [1] , Nurcan Berber [2]


Monastrol which is a kinesin-5 inhibitor have been synthesized using 3-hydroxybenzaldehyde, thiourea and ethylasetoasetate in the presence of Alumina Sulphonic Acid (ASA) catalyst in solvent free system. Charge transfer complexes between monastrol as a donor and acceptors such as tetracyanoquinomethane (TCNQ) and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) have been studied spectrophotometrically in acetonitrile at 21 oC. The stoichiometry of the complexes was found to be 1:1 ratio by the Job method between donor and acceptors with the maximum absorption band at a wavelength of 742nm and 546nm respectively. The equilibrium constants were determined by Benesi-Hildebrand and thermodynamic parameters of the complexes by Van’t Hoff equation.

Kinesin-5 inhibitörü olarak kullanılan Monastrol, çözücüsüz ortamda alümina sülfonik asit (ASA) katalizörü varlığında 3-hidroksibenzaldehit, tiyoüre ve etilasetoasetat kullanılarak sentezlenmiştir. Elektron verici (Donör, D) olarak monastrol, elektron alıcı (Akseptör, A) olarak tetrasiyanoquinometan (TCNQ) kullanılmış ve bunlar ile 2,3-dikloro-5,6-disiyano-p-benzokinon (DDQ) bileşikleri arasındaki yük transfer kompleksleri asetonitril içinde 21 °C'de spektrofotometrik olarak incelenmiştir. Komplekslerin stokiyometrisi, Job yöntemi kullanılarak incelenmiş, elektron verici ve alıcılar arasında TCNQ ile 742 nm ve DDQ ile 546 nm dalga boyunda maksimum absorbsiyon bandında 1:1 oranında olduğu bulunmuştur. Komplekslerin denge sabiti Benesi-Hildebrand ve termodinamik parametreleri Van't Hoff denklemi ile belirlenmiştir.

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Konular Mühendislik
Yayımlanma Tarihi Aralık 2016
Bölüm Araştırma Makalesi
Yazarlar

Yazar: Mustafa Arslan

Yazar: Nurcan Berber

Tarihler

Başvuru Tarihi : 13 Nisan 2016
Kabul Tarihi : 8 Haziran 2016
Yayımlanma Tarihi : 1 Aralık 2016

Bibtex @araştırma makalesi { saufenbilder270002, journal = {Sakarya University Journal of Science}, issn = {1301-4048}, eissn = {2147-835X}, address = {}, publisher = {Sakarya Üniversitesi}, year = {2016}, volume = {20}, pages = {425 - 431}, doi = {10.16984/saufenbilder.67697}, title = {Synthesis of Monastrol, Kinesin-5 inhibitör and ınvestigation of its charge transfer complexes}, key = {cite}, author = {Arslan, Mustafa and Berber, Nurcan} }
APA Arslan, M , Berber, N . (2016). Synthesis of Monastrol, Kinesin-5 inhibitör and ınvestigation of its charge transfer complexes. Sakarya University Journal of Science , 20 (3) , 425-431 . DOI: 10.16984/saufenbilder.67697
MLA Arslan, M , Berber, N . "Synthesis of Monastrol, Kinesin-5 inhibitör and ınvestigation of its charge transfer complexes". Sakarya University Journal of Science 20 (2016 ): 425-431 <http://www.saujs.sakarya.edu.tr/tr/issue/25594/270002>
Chicago Arslan, M , Berber, N . "Synthesis of Monastrol, Kinesin-5 inhibitör and ınvestigation of its charge transfer complexes". Sakarya University Journal of Science 20 (2016 ): 425-431
RIS TY - JOUR T1 - Synthesis of Monastrol, Kinesin-5 inhibitör and ınvestigation of its charge transfer complexes AU - Mustafa Arslan , Nurcan Berber Y1 - 2016 PY - 2016 N1 - doi: 10.16984/saufenbilder.67697 DO - 10.16984/saufenbilder.67697 T2 - Sakarya University Journal of Science JF - Journal JO - JOR SP - 425 EP - 431 VL - 20 IS - 3 SN - 1301-4048-2147-835X M3 - doi: 10.16984/saufenbilder.67697 UR - https://doi.org/10.16984/saufenbilder.67697 Y2 - 2016 ER -
EndNote %0 Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi Synthesis of Monastrol, Kinesin-5 inhibitör and ınvestigation of its charge transfer complexes %A Mustafa Arslan , Nurcan Berber %T Synthesis of Monastrol, Kinesin-5 inhibitör and ınvestigation of its charge transfer complexes %D 2016 %J Sakarya University Journal of Science %P 1301-4048-2147-835X %V 20 %N 3 %R doi: 10.16984/saufenbilder.67697 %U 10.16984/saufenbilder.67697
ISNAD Arslan, Mustafa , Berber, Nurcan . "Synthesis of Monastrol, Kinesin-5 inhibitör and ınvestigation of its charge transfer complexes". Sakarya University Journal of Science 20 / 3 (Aralık 2016): 425-431 . https://doi.org/10.16984/saufenbilder.67697
AMA Arslan M , Berber N . Synthesis of Monastrol, Kinesin-5 inhibitör and ınvestigation of its charge transfer complexes. SAUJS. 2016; 20(3): 425-431.
Vancouver Arslan M , Berber N . Synthesis of Monastrol, Kinesin-5 inhibitör and ınvestigation of its charge transfer complexes. Sakarya University Journal of Science. 2016; 20(3): 431-425.