Year 2017, Volume 21, Issue 3, Pages 395 - 402 2017-06-01

Examination of in vitro activities of some naphthalenyloxypropanol derivatives against multi-drug resistant bacteria
Naftaleniloksipropanol türevi bazı bileşiklerin çok ilaca dirençli bakterilere karşı in vitro etkinliklerinin incelenmesi

Hayriye Genç [1] , Oğuz Karabay [2] , Mustafa Zengin [3]

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Treatment of multi-drug resistant bacteria is a growing problem for the whole World and the need for new antibacterial drug is increasing day by day. Herein, oxipropanolamine derivatives from α-naphthol compound were synthesized and the activities against MDR (multi-drug resistant) bacteria were evaluated. Strains of S. aureus which is one of Gram-positive bacteria and A. baumannii, P. aeruginosa, E. coli which are of  Gram-negative bacteria were used.The tested bacteria are Gram-pozitif stain of S. aureus and Gram-negatif stains of A. baumannii, P. aeruginosa, E. coli. For the synthesis of compounds 2a-d which were used in the study, firstly   2-((naphthalen-1-yloxy)methyl) oxirane was obtained with the reaction of α-naphthol with epichlorohydrin and then reacted with four diffrent amine groups to obtain 2a-d derivatives. in vitro activities of these compounds against MDR bacteria were determined by the Kirby-Bauer method according to CLSI standards. While the obtained compounds 2a, 2b and 2c have more antibacterial activity than other tested antibacterials, the compound 2d has shown moderate or blow antibacterial activity against Gram-negative bacteria, but has a high activity against gram-positive bacteria S. aureus.

 Çoklu ilaca dirençli bakterilerin tedavisi bütün dünya için ciddi bir problem teşkil etmekte ve yeni antibakteriyellere olan ihtiyaç gün geçtikçe artmaktadır. Bu çalışmada, α-Naftol bileşiğinden oksipropanolamin türevleri sentezlenmiş ve ÇİD (çoklu ilaca dirençli) bakterilere karşı aktiviteleri değerlendirilmiştir. Gram-pozitif bakterilerden Staphylococcus aureus ve Gram-negatif bakterilerden A. baumannii, P. aeruginosa, E. coli suşları kullanılmıştır. Çalışmada kullanılan 2a-d bileşiklerinin sentezi için ilk olarak α-naftol ile epiklorohidrin reaksiyona sokularak 2-((naftelen-1-iloksi)metil)oksiran (1) bileşiği elde edilmiş ve ardından dört değişik amin türevi ile reaksiyona sokularak 2a-d türevleri elde edilmiştir. Bu bileşiklerin ÇİD bakterilere karşı in vitro etkinlikleri Kirby-Bauer metodu ile CLSI standartlarına göre belirlenmiştir. Elde edilen bileşiklerden 2a, 2b ve 2c her bir bakteri türüne karşı test edilen diğer antibakteriyellerden daha fazla antibakteriyel etkiye sahipken, 2d bileşiği Gram-negatif bakterilere karşı ortalama veya altında bir etkinlik göstermiş, Gram-pozitif bakteri olan S. aureus’ a karşı yüksek bir etkinlik sergilemiştir.

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Subjects Engineering, Chemical
Published Date Haziran 2017
Journal Section Research Articles
Authors

Author: Hayriye Genç

Author: Oğuz Karabay

Author: Mustafa Zengin

Dates

Publication Date: June 1, 2017

Bibtex @research article { saufenbilder296820, journal = {Sakarya University Journal of Science}, issn = {1301-4048}, eissn = {2147-835X}, address = {Sakarya University}, year = {2017}, volume = {21}, pages = {395 - 402}, doi = {10.16984/saufenbilder.296820}, title = {Examination of in vitro activities of some naphthalenyloxypropanol derivatives against multi-drug resistant bacteria}, key = {cite}, author = {Genç, Hayriye and Karabay, Oğuz and Zengin, Mustafa} }
APA Genç, H , Karabay, O , Zengin, M . (2017). Examination of in vitro activities of some naphthalenyloxypropanol derivatives against multi-drug resistant bacteria. Sakarya University Journal of Science, 21 (3), 395-402. DOI: 10.16984/saufenbilder.296820
MLA Genç, H , Karabay, O , Zengin, M . "Examination of in vitro activities of some naphthalenyloxypropanol derivatives against multi-drug resistant bacteria". Sakarya University Journal of Science 21 (2017): 395-402 <http://www.saujs.sakarya.edu.tr/issue/26996/296820>
Chicago Genç, H , Karabay, O , Zengin, M . "Examination of in vitro activities of some naphthalenyloxypropanol derivatives against multi-drug resistant bacteria". Sakarya University Journal of Science 21 (2017): 395-402
RIS TY - JOUR T1 - Examination of in vitro activities of some naphthalenyloxypropanol derivatives against multi-drug resistant bacteria AU - Hayriye Genç , Oğuz Karabay , Mustafa Zengin Y1 - 2017 PY - 2017 N1 - doi: 10.16984/saufenbilder.296820 DO - 10.16984/saufenbilder.296820 T2 - Sakarya University Journal of Science JF - Journal JO - JOR SP - 395 EP - 402 VL - 21 IS - 3 SN - 1301-4048-2147-835X M3 - doi: 10.16984/saufenbilder.296820 UR - https://doi.org/10.16984/saufenbilder.296820 Y2 - 0207 ER -
EndNote %0 Sakarya University Journal of Science Examination of in vitro activities of some naphthalenyloxypropanol derivatives against multi-drug resistant bacteria %A Hayriye Genç , Oğuz Karabay , Mustafa Zengin %T Examination of in vitro activities of some naphthalenyloxypropanol derivatives against multi-drug resistant bacteria %D 2017 %J Sakarya University Journal of Science %P 1301-4048-2147-835X %V 21 %N 3 %R doi: 10.16984/saufenbilder.296820 %U 10.16984/saufenbilder.296820
ISNAD Genç, Hayriye , Karabay, Oğuz , Zengin, Mustafa . "Examination of in vitro activities of some naphthalenyloxypropanol derivatives against multi-drug resistant bacteria". Sakarya University Journal of Science 21 / 3 (June 2017): 395-402. https://doi.org/10.16984/saufenbilder.296820
AMA Genç H , Karabay O , Zengin M . Examination of in vitro activities of some naphthalenyloxypropanol derivatives against multi-drug resistant bacteria. SAUJS. 2017; 21(3): 395-402.
Vancouver Genç H , Karabay O , Zengin M . Examination of in vitro activities of some naphthalenyloxypropanol derivatives against multi-drug resistant bacteria. Sakarya University Journal of Science. 2017; 21(3): 402-395.